Olive oil ingredient leads cancer cells to their death

An ingredient found in extra-virgin olive oil called oleocanthal has been known as a compound capable of killing a variety of human cancer cells, but how this process actually played out was not understood. Now, a team of researchers has uncovered not only how oleocanthal destroys cancer cells, but that it is able to do so while leaving healthy cells unharmed.

Paul Breslin, a professor of nutritional sciences at Rutgers University, had thought that oleocanthal killed the cancer cells by targeting a key protein in cancer cells that triggers apoptosis, a process that sees dangerous or damaged cells self-destruct by upsetting the balance of ions in the cell membranes. In investigating this theory, he teamed up with David Foster and Onica LeGendre, two cancer biologists from New York City’s Hunter College to more closely examine the process.

«We needed to determine if oleocanthal was targeting that protein and causing the cells to die,» says Breslin.

What first surprised the scientists was how quickly the oleocanthal destroyed the cancer cells. While apoptosis requires between 16 and 24 hours to take effect, the oleocanthal was killing off the cancer cells within 30 minutes to one hour. This led the team to believe that there were some other factors at play.

What they discovered was that the oleocanthal was piercing the cancer cell’s vesicles, the containers that store the cell’s waste. By puncturing these «dumpsters,» as Breslin describes them, it creates an outpouring of enzymes that then cause the cell to die.

«Once you open one of those things, all hell breaks loose,» says Breslin.

And when it came to the healthy cells, the researchers found that they remain completely unharmed. While the application of oleocanthal caused a temporary halt in their life cycles, after 24 hours they returned to normal.

With the testing thus far carried out in the lab, the researchers say that they will now look to establish the effects of oleocanthal on cancer cells in living animals.

The findings were published in the journal Molecular and Cellular Oncology.

Source: Rutgers University

Source: www.gizmag.com

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Demetrios Georgalas (A Surviving Globalization Consultant) was born in 1961 in Bern and grew up in Athens. In1985, graduated from Surrey University with a Tourism Management BSc (Hons). In 1998, graduated from LMTB under Freie Universitat Berlin, with a Diploma Lasers in Medicine. His professional career was started in the private sector and at the same time he created his first consulting company D+G Consultants Inc. Worked for major multinationals in Greece and abroad (FMCGs / Pharmaceuticals / Tourism). Demetrios Georgalas, having established also Travelling 2 Greece a destination management company, while with the D+G Consultants working in the areas of BTL and special marketing projects. He is activated except from Greece in the Balkans and in Turkey, consulting his clientele with new innovative proposals. Apart from his enterprising activities, he dabbles at blogging, travelling and cooking while he is married and has two children. In conclusion Demetrios Georgalas is an Athenian, Greek, Agnostic, Traveller, & Liberal he likes sci-fi, photography, blogging, travelling and cooking and if you like fascism or any kind of dogma, keep out! Δημήτρης Κ. Γεωργαλάς Γεννήθηκε στην Αθήνα το 1961, σπούδασε Τουριστική Διαχείριση στο Ηνωμένο Βασίλειο και κατέχει μεταπτυχιακό τίτλο στην Βιοτεχνολογία. Έχει εργαστεί σε μεγάλα τουριστικά γραφεία του εσωτερικού, και σε πολυεθνικές σε Ελλάδα και Εξωτερικό, στο χώρο των φαρμάκων, των ιατρικών μηχανημάτων και των FMCG’s. Από το 2001 είναι ελεύθερος επαγγελματίας, με δραστηριότητα στην διαχείριση προορισμού, τον θεματικό τουρισμό και τις ειδικές ενέργειες marketing. Είναι παντρεμένος και πατέρας δυο παιδιών, διδάσκει ειδικά θέματα εξωτερικού εμπορίου και κοινωνικής δικτύωσης, σε επιχειρήσεις και οργανισμούς. Ασχολείται ενεργά με το διαδίκτυο από το 1993 με άμεση εμπλοκή στα κοινωνικά δίκτυα και στο «ιστολογείν». Φανατικός ταξιδευτής, ερασιτέχνης φωτογράφος, μαχόμενος αγνωστικός και φιλελεύθερος. Όραμά του μια Ευρωπαϊκή Ελλάδα. https://brexians.wordpress.com
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